کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5040967 1473909 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Full-length ArticleLow-grade inflammation is a major contributor of impaired attentional set shifting in obese subjects
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Full-length ArticleLow-grade inflammation is a major contributor of impaired attentional set shifting in obese subjects
چکیده انگلیسی


- Sixty-six obese subjects and twenty normal-weight subjects were included.
- Obese subjects with higher levels of CRP (>5 mg/L) exhibited impaired cognitive flexibility.
- The group of obese subjects with lower CRP levels was similar to the control group.
- The role of CRP in altered cognitive flexibility in obesity was confirmed by regression analyses.
- Inflammation represents a major contributor of cognitive flexibility alterations in obesity.

Impairment in cognitive flexibility and set shifting abilities has been described in obesity. This alteration is critical as it can interfere with obesity management strategies. Recent evidences suggest that chronic low-grade inflammation may be involved in cognitive deficits associated with obesity, but the potential involvement in reduced flexibility remains unknown. The objective of this study was to assess the contribution of low-grade inflammation, determined by circulating levels of high-sensitivity C-reactive protein (hsCRP), in reduced cognitive flexibility and shifting abilities of obese subjects relatively to a group of non-obese participants. Performance in the intra/extra-dimensional set shift (IED) test, extracted from the CANTAB, was assessed in 66 obese subjects and 20 non-obese participants. Obese subjects with concentrations of hsCRP above 5 mg/L exhibited reduced performance on the IED test in comparison to obese subjects with lower levels of hsCRP and non-obese participants. This difference was particularly manifest in the number of errors made during the extra-dimensional shift (EDS errors). In contrast, performance before the extra-dimensional shift was spared. Linear regression analyses revealed that the association between obesity and IED alterations was significant only when the condition hsCRP >5 mg/L was entered in the model. These findings are important as they indicate that, rather than obesity itself, low-grade inflammation represents a major contributor of IED performance in obese subjects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 58, November 2016, Pages 63-68
نویسندگان
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