Disminución de la toxicidad y del efecto terapéutico del ácido zoledrónico en el tratamiento combinado con diferentes extractos antioxidantes

The use of antioxidant substances decreases the cytotoxic effect of zoledronic acid over non-tumour cells, and as such could be used in benign diseases. Furthermore, in the combined treatment using ionising radiation, these antioxidants also produced a protective effect in tumour cells, thus reducing the therapeutic effect sought by combining the treatment with radiation.