Synthesis of pyrazole fused pyran analogues: Antimicrobial, antioxidant and molecular docking studies

A series of six new pyrazole fused pyrans were synthesized by intramolecular cyclisation reaction of 3-(1-hydroxynaphthalen-2-yl)-1-aryl-1H-pyrazole-4-carbaldehydes with ethyl alcohol in the presence of conc. sulphuric acid under reflux conditions. The synthesized compounds were characterized by 1H NMR, 13C NMR, MS studies and elemental analysis, and were evaluated in vitro for their antimicrobial and antioxidant susceptibilities against different strains of bacteria, fungi, and DPPH and hydroxyl free radicals. Molecular docking of these compounds studied for their antimicrobial and antioxidant activities.