کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137223 | 1494536 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fermented garlic extract ameliorates monocrotaline-induced pulmonary hypertension in rats
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Fermented garlic extract ameliorates monocrotaline-induced pulmonary hypertension in rats Fermented garlic extract ameliorates monocrotaline-induced pulmonary hypertension in rats](/preview/png/5137223.png)
چکیده انگلیسی
This study investigated the effect of fermented garlic extract (FGE) on pulmonary hypertension in monocrotaline (MCT)-treated rats. Sprague-Dawley rats were subcutaneously injected with either 50Â mg/kg MCT or a vehicle 3Â days after the FGE feeding (0.97Â mg nitrite/ml/day) was initiated. MCT treatment increased the weight, systolic pressure, and atrial natriuretic peptide concentration in the right ventricle but not in the left ventricle. FGE feeding attenuated these effects as well as the endothelial damage and medial hypertrophy of the pulmonary arterioles and the pulmonary fibrosis induced by MCT. These FGE effects were blocked by a soluble guanylyl cyclase (sGC) inhibitor. Increases in VCAM-1 and MMP-9 protein expressions, and decreases in PKG and eNOS protein expressions in the lung of MCT rats were attenuated by FGE feeding. These findings suggest that FGE ameliorates MCT-induced pulmonary hypertension by decreasing the inflammatory reaction via the NO-sGC-PKG pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 30, March 2017, Pages 247-253
Journal: Journal of Functional Foods - Volume 30, March 2017, Pages 247-253
نویسندگان
Byung Mun Park, Hyunsoo Chun, Soo Wan Chae, Suhn Hee Kim,