کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137323 | 1494529 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phytoecdysteroid-enriched quinoa seed leachate enhances healthspan and mitochondrial metabolism in Caenorhabditis elegans
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
DCF-DA20HEPhytoecdysteroid20-HydroxyecdysoneOCRFCCPC. elegansDcf2′,7′-dichlorodihydrofluorescein diacetate - 2 '، 7'-dichlorodihydrofluorescein diacetate2′,7′-dichlorofluorescein - 2 '، 7'-dichlorofluoresceinROS - ROSRespiration - تنفسAging - سالخوردگیAge - سنPhysical performance - عملکرد فیزیکیAdvanced glycation end-product - محصول نهایی پیشرفته glycationOxygen consumption rate - میزان مصرف اکسیژنcarbonylcyanide-p-trifluoromethoxyphenylhydrazone - کربونیل سایانیید-پتروفورورمتوکسفنیل هیدرازونQuinoa - کوینوReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Quinoa (Chenopodium quinoa Willd.) phytochemicals have exhibited metabolic benefit in mammals, though their effects on aging and mechanisms of action remain unknown. Caenorhabditis elegans offers a practical in vivo model to study bioactivity since major metabolic pathways are conserved across phyla. We explored the effects of phytoecdysteroid-enriched quinoa seed preparation, termed quinoa leachate (QL), on behavioral and biochemical endpoints of wild-type C. elegans health. QL treatment (1.0Â mg/mL or less) increased median lifespan from 9 to 11Â d, improved locomotory performance from 103.5 to 114.9 head thrashes/min, and enhanced basal respiration rate by 37%. QL also reduced advanced glycation end-product (AGE) pigments by 24%, reactive oxygen species (ROS) by 20%, and body fat by 14%. 20-Hydroxyecdysone (20HE), the primary phytoecdysteroid in QL, conferred statistically similar benefit compared to QL at equivalent doses. Data suggest that quinoa supplementation slows C. elegans aging and improves metabolic health, and 20HE is the primary bioactive constituent responsible for favorable effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 37, October 2017, Pages 1-7
Journal: Journal of Functional Foods - Volume 37, October 2017, Pages 1-7
نویسندگان
Brittany L. Graf, Shaunak Kamat, Kuan Yu Cheong, Slavko Komarnytsky, Monica Driscoll, Rong Di,