کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137454 | 1494539 | 2016 | 13 صفحه PDF | دانلود رایگان |
- β-Casofensin, a milk bioactive peptide, prevented intestinal hyperpermeability induced by neonatal stress.
- This effect was accompanied by preservation of the intestinal goblet cells.
- β-Casofensin also prevented the hyperplasia of enteroendocrine cells induced by neonatal stress.
- β-Casofensin maintained its effects when administered in a casein matrix.
- Moreover, a casein matrix with β-casofensin protected against indomethacin-induced enteritis.
β-Casofensin is a milk-derived bioactive peptide that interacts with intestinal goblet cells. We aimed to determine whether β-casofensin could prevent intestinal dysfunctions induced by neonatal maternal separation (NMS) and whether it retains its protective effects when administered in a casein matrix. We also evaluated whether a casein matrix enriched in β-casofensin protects against intestinal enteritis induced by indomethacin. β-Casofensin abolished NMS-induced jejunal hyperpermeability and prevented the depletion of goblet and Paneth cells induced by NMS. In addition, β-casofensin maintained its effectiveness against NMS-induced intestinal barrier alterations when administered in a casein matrix. A casein matrix containing β-casofensin also reduced intestinal damages induced by indomethacin. A functional food containing β-casofensin may prevent both the deleterious effects of neonatal stress on the intestinal barrier and indomethacin-induced enteritis. These results suggest a promising application of β-casofensin as a gut barrier protector in the context of bioactive foods and clinical nutrition.
Journal: Journal of Functional Foods - Volume 27, December 2016, Pages 223-235