کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137491 | 1494539 | 2016 | 8 صفحه PDF | دانلود رایگان |
- An effective method for isolating [6]-Gingerol from ginger was established.
- An optimal formulation of [6]-Gingerol-loaded-SMEDDS was successfully developed.
- In vitro release profile of [6]-Gingerol from SMEDDS was significantly enhanced.
- The SMEDDS effectively improved the oral bioavailability of [6]-Gingerol.
The purpose of this study was to develop a [6]-Gingerol-loaded self-microemulsifying drug delivery system ([6]-Gingerol-SMEDDS) for oral administration and enhanced bioavailability of the drug. The [6]-Gingerol-SMEDDS, consisting of oils (ethyl oleate), surfactant (Cremophor EL35) and co-surfactant (1,2-propanediol), showed an acceptable spherical nanoparticle with stable physicochemical properties such as the mean droplet size (73.06â±â0.49ânm), zeta potential (â2.45â±â0.41) and encapsulation efficiency (89.40â±â1.11%). The in vitro release of [6]-Gingerol from the delivery system in the three different media (HCl, pHâ1.2; Double distilled water, pHâ7.0; phosphate buffer solution, pHâ7.4) was significantly higher than in the free drug. The [6]-Gingerol-SMEDDS also exhibited prolonged plasma circulation which led to 6.58-fold increase in oral bioavailability compared with the free drug. These findings indicated that the developed [6]-Gingerol-SMEDDS could be a promising alternative in improving the solubility and oral bioavailability of [6]-Gingerol, as well as increasing its biological applications.
Journal: Journal of Functional Foods - Volume 27, December 2016, Pages 703-710