کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137528 | 1494538 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Virgin olive oil enriched with its own phenolic compounds or complemented with thyme improves endothelial function: The potential role of plasmatic fat-soluble vitamins. A double blind, randomized, controlled, cross-over clinical trial
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کلمات کلیدی
Plasminogen activator inhibitor type IGPXICAM-1MCP-1IrhPAI-1hsCRPNOx - NOXUPLC-MS/MS - UPLC-MS / MSPhenolic compounds - ترکیبات فنولیTriglycerides - تریگلیسریدIntercellular cell adhesion molecule - مولکول چسبندگی سلول بین سلولیNitric oxide - نیتریک اکسیدmonocyte chemotactic protein - پروتئین chemotactic monocytehigh sensitivity C-reactive protein - پروتئین واکنش پذیر C با حساسیت بالاhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراInternational Conference of Harmonization - کنفرانس بین المللی هماهنگیglutathione peroxidase - گلوتاتیون پراکسیداز
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of the present study was to assess whether different functional virgin olive oils (FVOOs) with varying phenolic compounds (PC) could protect the plasmatic fat-soluble vitamins, which in turn could improve the endothelial function. In order to select the optimal phenolic dose in the improvement of ischemic reactive hyperemia (IRH), a dose-response study (n = 12, healthy subjects) was performed and the enrichment of 500 mg PC/kg oil was selected. In a 3-week cross-over sustained study (n = 33 hypercholesterolemic subjects), the consumption of 25 mL/day of two phenol-enriched olive oils (one enriched with its own PC and another combined with thyme PC) increased IRH and plasma concentrations of retinol, β-cryptoxanthin and α-tocopherol, compared to a control virgin olive oil. A positive post-intervention correlation was observed for IRH values and HDL-c, β-cryptoxanthin, lutein and α-tocopherol. Results suggest that preservation of plasmatic fat-soluble vitamins by PC from FVOOS could partially explain the endothelial function benefits.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 28, January 2017, Pages 285-292
Journal: Journal of Functional Foods - Volume 28, January 2017, Pages 285-292
نویسندگان
Rosa-M. Valls, Marta Farrà s, Anna Pedret, Sara Fernández-Castillejo, Ãrsula Catalán, Marta Romeu, Montse Giralt, Guillermo-T. Sáez, Montserrat Fitó, Rafael de la Torre, MarÃa-Isabel Covas, MarÃa-José Motilva, Rosa Solà , Laura Rubió,