Changes in paracellular permeability induced by Pepsin-Trypsin digested Gliadin (PTG): Role of polyamines in the Lactobacillus rhamnosus GG protective action

The results from this study clearly indicate that L.GG protects Caco-2 cells from PTG induced damage and, interestingly, the presence of cellular polyamines seems to be essential in the modulation of TJ and AJ protein expression exerted by this probiotic. On these bases, a role for L.GG as a dietary supplement to promote health also for CD patients could be hypothesized.