کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137559 | 1494530 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polyphenols and tri-terpenoids from Olea europaea L. in alleviation of enteric pathogen infections through limiting bacterial virulence and attenuating inflammation
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کلمات کلیدی
CFUTNFTTSSSalmonella enterica serovar TyphimuriumEHECMBCMICEnterohemorrhagic Escherichia coli - Escherichia coli EnterohemorrhagicMOI - MEOleanolic acid - اسید اولانیولیکMaslinic acid - اسید ماسلینیکOleuropein - اولوروپینminimum bactericidal concentration - حداقل غلظت باکتریMinimum inhibitory concentration - حداقل غلظت مهاریType III secretion system - سیستم ترشحی نوع IIIAnti-inflammation - ضد التهابtumor necrosis factor - فاکتور نکروز تومورHydroxytyrosol - هیدروکسی تیروسولProbiotic - پروبیوتیکPolyphenol - پلی فنلmultiplicity of infection - چندین عفونتcolony forming unit - کلنی واحد تشکیل
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Olea europaea L. was known associated with health benefits, however the role of single bioactive component remains to be elucidated. This study was to investigate the operational feasibility of maslinic/oleanolic acid, hydroxytyrosol, and oleuropein from olive in control and alleviation of enteric pathogen infections. Our results indicated that the growth of Lactobacillus was stimulated by maslinic/oleanolic acid up to 4% (w/v) in dose-dependent manner. Hydroxytyrosol (>0.05%) and oleuropein (>0.5%) significantly reduced Salmonella Typhimurium/EHEC within 12Â h, altered their physicochemical properties, influenced host cell-pathogen interactions, and especially 0.6-6.0 folds down-regulated the virulence gene expressions. Further molecular analysis revealed that these olive compounds up-regulated anti-inflammatory cytokine IL-10 gene by 3.0-8.0 folds and down-regulated multiple inflammation related genes at various levels. These results suggest that polyphenols in olive may serve as potential preservatives in post-harvest food processing while tri-terpenoids may assist in modulation of gut microflora and reduction of enteric pathogen colonization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 36, September 2017, Pages 132-143
Journal: Journal of Functional Foods - Volume 36, September 2017, Pages 132-143
نویسندگان
Mengfei Peng, Xi Zhao, Debabrata Biswas,