Dietary fibre and phenolic-rich extracts from Musa paradisiaca inflorescence ameliorates type 2 diabetes and associated cardiovascular risks

The present study investigated nutraceutical properties of Musa paradisiaca (Nendran variety) inflorescence (PI). PI was found to be a rich source of soluble (SDF) and insoluble dietary fibre (12.45 and 53.31% respectively). SDF exhibited potential glucose and cholesterol adsorption capacity. Ethyl acetate (PIE) and methanol (PIM) extracts of PI were analyzed for phenolics content, antioxidant activities, antidiabetic and cardiovascular protection efficacy. PIM exhibited significant ABTS free radical scavenging activity (IC50-57.2 ± 1.15 μg/mL) and inhibited the production of reactive oxygen species in L6 myoblasts in a dose-dependent manner. PIM also demonstrated potential inhibition of carbohydrate digestive enzymes (α-amylase and α-glucosidase), interfered with the production of glycated end products (IC50-142.27 ± 1.09 μg/mL) and enhanced glucose uptake in L6 myoblasts. PIM inhibited LDL oxidation (IC50-169.52 ± 1.77 μg/mL) and ACE, indicating its protective role against cardiovascular risk factors. The study demonstrated the nutraceutical potential of PI in ameliorating type 2 diabetes and associated cardiovascular problems.