کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137935 | 1494591 | 2017 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of the absolute configuration of a novel tetrasubstituted isoindolinone by vibrational circular dichroism
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The absolute configuration of a recently prepared asymmetric 3,3-disubstituted isoindolinone (ethyl 2-benzyl-3-oxo-1-(3-oxobutyl)isoindoline-1-carboxylate), possessing highly promising pharmaceutical activity, has been determined by means of VCD spectroscopy and DFT calculations. The great flexibility of the molecule reduces to a few relevant conformers, all contributing in the same way to the shape of the VCD spectrum for the carbonyl stretching region. Two of the three CO groups of the molecule interact with each other during the stretching vibration, thus providing a non-conservative VCD couplet whose signature, together with the VCD sign of the third CO stretching mode, unequivocally determines the absolute configuration of the molecule, which is found to be (S) for the (-) optical isomer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 144, 10 September 2017, Pages 52-58
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 144, 10 September 2017, Pages 52-58
نویسندگان
Antonio Massa, Paola Rizzo, Francesco Scorzelli, Guglielmo Monaco, Riccardo Zanasi,