کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5138224 1494605 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical feasibility of dried blood spots: Analytics, validation, and applications
ترجمه فارسی عنوان
امکان سنجی بالینی از نقاط خون خشک: تجزیه و تحلیل، اعتبار، و برنامه های کاربردی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Dried blood spots (DBS) sampling and their specific advantages are becoming common in analytical and clinical routine. Being first established for metabolic disorder screening in neonates, its use emerged to a broad spectrum of clinical applications. Although DBS are easily generated, the conduction of specific analytical and clinical validation procedures should be obligatory when implementing DBS for clinical purposes, e.g. therapeutic drug monitoring or clinical drug trials. A respective recommendation has already been published by the European Bioanalysis Forum. Since no official guidelines are present, investigators are currently free in DBS procedure development and validation. This review summarizes and discusses published clinical validation procedures in relation to their applications to highlight the clinical feasibility of DBS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 130, 25 October 2016, Pages 231-243
نویسندگان
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