کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5141751 1379089 2016 31 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mass spectrometry in the therapeutic drug monitoring of direct oral anticoagulants. Useful or useless?
ترجمه فارسی عنوان
طیف سنجی جرمی در نظارت داروهای موضعی ضد انعقادی خوراکی. مفید یا بی فایده؟
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Direct oral anticoagulants (DOACs) are now widely used in various thromboembolic diseases. Although routine therapeutic drug monitoring is not required, cumulative evidence suggests the usefulness of point measurement in some situations. Mass spectrometry is highly sensitive and specific and is considered the gold standard for the accurate measurement of DOAC plasma concentrations. However, lack of 24/7 availability, labour-intensive sample preparation and slow turn-around time of the analysis reduce its usefulness in emergency situations. Several coagulation or chromogenic assays have been introduced to estimate the plasma concentration of DOACs. In daily practice, these assays are recommended in most cases since they provide sufficient agreement with mass spectrometry over a broad range of concentrations. However, the assays are not perfect, and improvements are required to increase their sensitivity and/or specificity. This article focuses on the pros and the cons of mass spectrometry and specific coagulation/chromogenic assays.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: TrAC Trends in Analytical Chemistry - Volume 84, Part B, November 2016, Pages 41-50
نویسندگان
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