کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5150853 1498699 2016 46 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs
چکیده انگلیسی
The clinical success of platinum-based chemotherapeutic agents was of enormous impact on the discovery of novel metal N-heterocyclic carbene (NHC) complexes as potential anti-cancer drugs. During the last years, the research on cytotoxic transition metal (e.g. Ag, Au, Pt, Pd, Cu, Hg, Ru, Os, Rh and Ir) NHC complexes was successful and the results are remarkable. In this review, we provide an update on the recent advances in this direction, which reflects new discoveries since the publication of our previous review. The anti-tumor properties along with the mechanisms of action for these complexes as well as possible structure-activity relationships are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Coordination Chemistry Reviews - Volume 329, 15 December 2016, Pages 191-213
نویسندگان
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