Rat liver mitochondrial dysfunction by addition of copper(II) or iron(III) ions

The Copper(II) and Iron(III) addition to isolated rat liver mitochondria produced decreased rates of mitochondrial respiration and oxygen consumption in active state 3 and phospholipid peroxidation by a Fenton/Haber Weiss mechanism of oxidative damage. Slightly different responses to the metal ions suggest some differences in the mechanism of intracellular toxicity.294