کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5156578 | 1500582 | 2017 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nanohybrid hydrogels of laponite: PVA-Alginate as a potential wound healing material
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Nanohybrid hydrogels of laponite: PVA-Alginate as a potential wound healing material Nanohybrid hydrogels of laponite: PVA-Alginate as a potential wound healing material](/preview/png/5156578.png)
چکیده انگلیسی
The aim of this study was to develop a novel nanohybrid interpenetrating network hydrogel composed of laponite:polyvinyl alcohol (PVA)-alginate (LAP:PVA-Alginate) with adjustable mechanical, physical and biological properties for wound healing application. Results demonstrated that compared to PVA-Alginate, mechanical strength of LAP:PVA-Alginate significantly enhanced (upon 2 times). Moreover, incorporation of 2Â wt.% laponite reduced swelling ability (3 times) and degradation ratio (1.2 times) originating from effective enhancement of crosslinking density in the nanohybrid hydrogels. Furthermore, nanohybrid hydrogels revealed admirable biocompatibility against MG63 and fibroblast cells. Noticeably, MTT assay demonstrated that fibroblast proliferation significantly enhanced on 0.5Â wt.% LAP:PVA-alginate compared to PVA-alginate. Moreover, hemolysis and clotting tests indicated that the nanohybrid hydrogels promoted hemostasis which could be helpful in the wound dressing. Therefore, the synergistic effects of the nanohybrid hydrogels such as superior mechanical properties, adjustable degradation rate and admirable biocompatibility and hemolysis make them a desirable candidate for wound healing process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 176, 15 November 2017, Pages 392-401
Journal: Carbohydrate Polymers - Volume 176, 15 November 2017, Pages 392-401
نویسندگان
Nasim Golafshan, R. Rezahasani, M. Tarkesh Esfahani, M. Kharaziha, S.N. Khorasani,