کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5156743 1500580 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-cytotoxic hybrid bioscaffolds of chitosan-silica: Sol-gel synthesis, characterization and proposed application
ترجمه فارسی عنوان
بیوساکسفولد هیبرید غیر سیتوتوکسیک کیتوزان سیلیکا: سنتز سل ژل، مشخصه و کاربرد پیشنهاد شده
کلمات کلیدی
کیتوزان، ترکیبی، بایوسافلد، بازسازی استخوان، سل ژل، سمیت مسمومیت،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Biohybrid chitosan-silica scaffolds were synthesized through the sol-gel and the freeze drying processes. Hydrolysis and condensation of chitosan with tetraethylorthosilicate (TEOS) in the presence of 3-isocyanatopropyl triethoxysilane (ICPTES) were successfully carried out. Results obtained from FTIR, swelling test and pyrolysis confirmed that the hybrid scaffolds containing covalent coupling between the organic and inorganic networks were formed with high crosslink density of SiOSi bridging and could be classified as the class II material. The hybridization also resulted in improvements on mechanical strength and stability comparing to the pure chitosan. In vitro investigations on the guided bone regeneration and the cytotoxicity were also performed. SEM-EDS was used to examine the proliferation of calcium phosphate mineral at the scaffold surface after an immersion in simulated body fluid. The results revealed that the hybrid scaffolds exhibited a rapid induction of calcium phosphate mineral without cytotoxicity effect, reflecting an excellent in vitro bone bioactivity which was superior to the pure chitosan scaffold.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 178, 15 December 2017, Pages 190-199
نویسندگان
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