کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5157451 | 1500585 | 2017 | 60 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A rhamnan-type sulfated polysaccharide with novel structure from Monostroma angicava Kjellm (Chlorophyta) and its bioactivity
ترجمه فارسی عنوان
پلی ساکارید سولفات شده با رحمانن با ساختار جدیدی از مونواستروما آنژیواواژل (کلروفیتا) و زیست سازگاری آن
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کلمات کلیدی
D-glucuronic acid (PubChem CID: 94715)Metformin (PubChem CID: 4091)Rhamnose (PubChem CID: 25310)Heparin (PubChem CID: 25244225)Palmitic acid (Pubchem CID: 985) - اسید پالمیتیک (Pubchem CID: 985)Dimethyl sulfoxide (PubChem CID: 679) - دی متیل سولفوکسید (PubChem CID: 679)Structure - ساختار یا سازهAntidiabetic activity - فعالیت ضددردیSulfated polysaccharide - پلی ساکارید سولفاتPyridine (PubChem CID: 1049) - پیریدین (PubChem CID: 1049)
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
A homogeneous polysaccharide was obtained from Monostroma angicava Kjellm by water extraction, preparative anion-exchange and size-exclusion chromatography. Results of chemical and spectroscopic analyses showed that the polysaccharide was a glucuronic acid-containing rhamnan-type sulfated polysaccharide. The backbone mainly consisted of â3)-α-l-Rhap-(1â and â2)-α-l-Rhap-(1â residues, partially sulfated at C-2 of â3)-α-l-Rhap-(1â and C-3/C-4 of â2)-α-l-Rhap-(1â. The branching contained unsulfated or monosulfated 3-linked, 2-linked, 4-linked α-l-rhamnose and terminal β-d-glucuronic acid residues. The polysaccharide had strong antidiabetic activity assessed by glucose consumption, total cholesterol and triglyceride levels using human hepatocellular carcinoma (HepG2) and insulin-resistant HepG2 cells. The polysaccharide exhibited high anticoagulant property by activated partial thromboplastin time and thrombin time assays, and possessed high fibrin(ogen)olytic activity evaluated by plasminogen activator inhibitior-1, fibrin(ogen) degradation products and D-dimer levels using rats plasma. The investigation demonstrated that the polysaccharide from Monostroma angicava Kjellm was a novel sulfated rhamnan and could be a potential antidiabetic and anticoagulant polysaccharide.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 173, 1 October 2017, Pages 732-748
Journal: Carbohydrate Polymers - Volume 173, 1 October 2017, Pages 732-748
نویسندگان
Xue Liu, Jiejie Hao, Xiaoxi He, Shuyao Wang, Sujian Cao, Ling Qin, Wenjun Mao,