کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5157792 | 1500601 | 2017 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pectin-silica gels as matrices for controlled drug release in gastrointestinal tract
ترجمه فارسی عنوان
ژل پلاتین-سیلیکا به عنوان ماتریس برای کنترل دارویی کنترل شده در دستگاه گوارش
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کلمات کلیدی
Ethanol (PubChem CID: 702) - اتانول (PubChem CID: 702)Hydrochloric acid (PubChem CID: 313) - اسید هیدروکلریک (PubChem CID: 313)Controlled release - انتشار کنترل شدهTexture analysis - تجزیه و تحلیل بافتFTIR spectra - طیف FTIRMesalazine - مازالازینPotassium dihydrogen phosphate (Pubchem CID: 516951) - پتاسیم دی هیدروژن فسفات (Pubchem CID: 516951)Sodium chloride (PubChem CID: 5234) - کلرید سدیم (PubChem CID: 5234)Calcium chloride (PubChem CID: 5284359) - کلرید کلسیم (PubChem CID: 5284359)
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
The synthesis of pectin-silica gels for controlled drug release in gastrointestinal tract (GIT) using low methoxyl (LM) and high methoxy (HM) pectins and tetraethoxysilane (TEOS) as precursor is described. The FTIR spectra of the pectin-silica gels show intense absorption bands at 1246Â cmâ1 and 802Â cmâ1 corresponding to the vibrations COSi bonds, which absent in the FTIR spectra of the native pectins that indicate the formation covalent bond between silica and pectin macromolecules in the pectin-silica gels. Pectin-TEOS, pectin-Ca-TEOS and pectin-TEOS-Ca beads with mesalazine are synthesized by different combinations of sol-gel method using TEOS and ionotropic gelation method using calcium chloride. The best resistant of pectin-TEOS and pectin-Ca-TEOS beads during incubation in simulated gastric fluid for 2Â h and subsequently in simulated intestinal fluids for 18Â h is indicated. Pectin-TEOS beads are characterized by higher encapsulation efficiency (to 28%) than pectin-Ca-TEOS beads (to 16%). The drug release of pectin-silica beads in simulated GIT occurs gradually up to 80% and is directly dependent on the hardness of the beads. The surface morphology of beads is shown. The use of pectin-silica beads is promising with regard to the development of controlled release of drug formulations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 157, 10 February 2017, Pages 9-20
Journal: Carbohydrate Polymers - Volume 157, 10 February 2017, Pages 9-20
نویسندگان
Fedor V. Vityazev, Maiia I. Fedyuneva, Victoria V. Golovchenko, Olga A. Patova, Elena U. Ipatova, Eugene A. Durnev, Ekaterina A. Martinson, Sergey G. Litvinets,