Prenylated flavonoids from Artocarpus altilis: Antioxidant activities and inhibitory effects on melanin production

► Five flavonoids, and 12 known compounds, were isolated from Artocarpus altilis. ► Natural antioxidants and tyrosinase inhibitors of A. altilis were identified. ► The inhibition modes of active compounds on tyrosinase were identified. ► Some prenylated flavones were demonstrated to reduce melanin production.