Cytotoxic cardenolide glycosides from the root of Reevesia formosana

► Thirteen cardenolide glycosides were isolated from R. formosana in the Sterculiaceae. ► Identification of sugars and unusual 18,20-epoxide cardenolide glycosides. ► Reevesiosides A, F, and epi-reevesioside F displayed potent cytotoxicity.