Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp. alpestre

Docking studies using 3D model of EeAChE provided rationale for low inhibitory activity of lycopodane-type alkaloids from Lycopodium annotinum, as well as hints for future structure-based design. Along with isolation of a new alkaloid, NMR and conformational data for several classical Lycopodium alkaloids are reported.