Coniferin dimerisation in lignan biosynthesis in flax cells

The use of [8,9-13C2]-coniferin coupled with mass spectrometry and nuclear magnetic resonance showed the ability of a flax cell suspension to biosynthesise differently linked (neo)lignans: 8-8′, 8-5′ and 8-O-4′. The continuous synthesis and subsequent metabolisation of these coniferin-derived dimers were established all over the culture period.