An in vitro and in silico approach to cholinesterase inhibitory and antioxidant effects of the methanol extract, furanocoumarin fraction, and major coumarins of Angelica officinalis L. fruits

► The methanol extract, furanocoumarin fraction and the major coumarins of the fruits of Angelica officinalis L. were tested against cholinesterase enzyme inhibitory and antioxidant activity. ► Imperatorin, xanthototixn, and bergapten showed a higher and selective inhibition against BChE. ► The samples showed antioxidant activity from ignorable to moderate level. ► Molecular docking simulations of the tested coumarins into BChE confirmed the strong interactions between them.