کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5202871 | 1381912 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stability of a salicylate-based poly(anhydride-ester) to electron beam and gamma radiation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Stability of a salicylate-based poly(anhydride-ester) to electron beam and gamma radiation Stability of a salicylate-based poly(anhydride-ester) to electron beam and gamma radiation](/preview/png/5202871.png)
چکیده انگلیسی
The effect of electron beam and gamma radiation on the physicochemical properties of a salicylate-based poly(anhydride-ester) was studied by exposing polymers to 0 (control), 25 and 50 kGy. After radiation exposure, salicylic acid release in vitro was monitored to assess any changes in drug release profiles. Molecular weight, glass transition temperature and decomposition temperature were evaluated for polymer chain scission and/or crosslinking as well as changes in thermal properties. Proton nuclear magnetic resonance and infrared spectroscopies were also used to determine polymer degradation and/or chain scission. In vitro cell studies were performed to identify cytocompatibility following radiation exposure. These studies demonstrate that the physicochemical properties of the polymer are not substantially affected by exposure to electron beam and gamma radiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 96, Issue 9, September 2011, Pages 1625-1630
Journal: Polymer Degradation and Stability - Volume 96, Issue 9, September 2011, Pages 1625-1630
نویسندگان
Roselin Rosario-Meléndez, Linda Lavelle, Stanko Bodnar, Frederick Halperin, Ike Harper, Jeremy Griffin, Kathryn E. Uhrich,