کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5202918 | 1381913 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparative analysis of commercial dermal fillers based on crosslinked hyaluronan: Physical characterization and in vitro enzymatic degradation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comparative analysis of commercial dermal fillers based on crosslinked hyaluronan: Physical characterization and in vitro enzymatic degradation Comparative analysis of commercial dermal fillers based on crosslinked hyaluronan: Physical characterization and in vitro enzymatic degradation](/preview/png/5202918.png)
چکیده انگلیسی
Filler swelling properties, soluble HA fraction and rheological behaviour were investigated. Furthermore the relative stability to enzymatic hydrolysis was tested. The presence of soluble HA in the formulations varied from 7 ± 1(%) to 33 ± 5(%) with respect to the total HA concentration. Chromatographic analyses showed that the soluble fractions consist of low molecular weight chains (Mw: 260-480 kDa) presenting large distributions (Mw/Mn: 1.6-2.5). The investigated fillers were found to be non-equilibrium gels in their commercial formulation also showing different swelling capacities. Rheological measurements indicated a shear thinning behaviour for all the products and elastic modulus values varied over a wide range (100-1800 Pa). Fillers proved differently sensitive to enzymatic degradation. Swelling capacity and enzymatic stability were found consistently dependent on the total HA concentration, insoluble/soluble HA ratio and on the crosslinking extent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 96, Issue 4, April 2011, Pages 630-636
Journal: Polymer Degradation and Stability - Volume 96, Issue 4, April 2011, Pages 630-636
نویسندگان
Annalisa La Gatta, Chiara Schiraldi, Agata Papa, Mario De Rosa,