کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5206087 1502947 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Material propertiesEffect of starch content on the biodegradation of polycaprolactone/starch composite for fabricating in situ pore-forming scaffolds
ترجمه فارسی عنوان
خواص مواد اثرات محتوای نشاسته بر تجزیه بیولوژیکی کامپوزیت پلی کاپرولاکتون / نشاسته برای ساخت داربست های تشکیل دهنده منافذ در محل
کلمات کلیدی
پلی کاپرولکتون، نشاسته، شکل گیری ذرات درون، مهندسی بافت استخوانی، تجزیه زیستی، قطر بینی،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

Bone tissue engineering is an efficient approach to regenerating bone-related defects. The optimal scaffold used for bone tissue engineering must possess adequate porosity and suitable mechanical properties. This work described the development of a biodegradable polymeric composite based on polycaprolactone (PCL) and starch that can form a porous structure in situ. The scaffold exhibited the required mechanical properties at the initial stage of implantation by controlling in situ degradation and subsequent pore formation. PCL/starch (SPCL) scaffolds with 100/0, 70/30, and 50/50 ratios were developed. Degradation studies were performed in phosphate buffer saline (PBS) containing α-amylase or lipase at 37 °C for 4 weeks. Fourier-transform infrared spectroscopy was used to analyze chemical bonds and their changes after degradation. Differential scanning calorimetry was applied to determine the crystallinity and recrystallization of samples before and after degradation. Mass loss and starch release were observed during degradation, and the porosity of samples was measured by the ethanol replacement method. Morphology was further determined using scanning electron microscopy. Finally, variations in compressive strength and modulus during degradation and pore formation were also measured. The porosity of samples reached 45% after 1 month of degradation, and mechanical properties were still appropriate for human bone tissue. Reduction in mechanical property after mass loss, starch release and pore formation was controlled by the hydrogen bonding and recrystallization effect of PCL after degradation. Results suggested that SPCL composite had potential to form porous scaffold with adequate mechanical properties in situ and is promising for bone tissue engineering applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Testing - Volume 43, May 2015, Pages 94-102
نویسندگان
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