کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5208386 | 1382570 | 2012 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biomimetic catalysts designed on macromolecular scaffolds
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کلمات کلیدی
Carboxypeptidase AGSTGPXDAPNPPPEICDNBPQQPCDSMCsGBNpNPPLcstBiomacromoleculesPNIPAMSupramoleculesGRX1CuOOH6HDNOTSAsGSHCTABNPACPADTTTCPP1-chloro-2,4-dinitrobenzene - 1-کلرو-2،4-دینیتروبنزنp-Nitrophenyl acetate - p-نیترفنیل استاتp-nitrophenyl phosphate - p-نیترفنیل فسفاتROS - ROSγ-Globulin - γ-گلوبولینArtificial enzyme - آنزیم مصنوعیPolymers - بسپار یا پلیمر Tris(2-aminoethyl)amine - تریس (2-aminoethyl) آمینLower critical solution temperature - دمای محلول بحرانی پایینDiphenyl diselenide - دیفنیل دیئلنیدdithiothreitol - دیتیوتریتولSOD - سدSmooth muscle cells - سلول های عضله صافSuperoxide dismutase - سوکسوکس دیسموتازCyclodextrin - سیکلودکسترینTREN - قطارhomovanillic acid - هومووانیلیک اسیدHexadecyltrimethylammonium bromide - هگزادیدیل تریمتیل آمونیوم برومیدHydroperoxides - هیدروپراکسیدHydroperoxide - هیدروپراکسیدPAMAM - پامامPoly(N-isopropylacrylamide) - پلی (N-isopropylacrylamide)poly(amidoamine) - پلی آمیدامینPolyethylenimine - پلی اتیلنHVA - چهBiomimetic catalyst - کاتالیزور BiomimeticGlutathione - گلوتاتیونGlutathione transferase - گلوتاتیون ترانسفرازglutathione reductase - گلوتاتیون ردوکتازglutathione peroxidase - گلوتاتیون پراکسیدازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Enzyme, an efficient and sophisticated biocatalyst, evolves into unique biomacromolecule with three-dimensional structure consisting of a linear sequence of amino acids and plays a crucial role in catalyzing biologically chemical reactions with high efficiency and selectivity in living system. For understanding the relationships between the enzyme structures and functions, the enzymatically catalytic mechanism, as well as for the potential applications, various biomimetic catalysts have been constructed to simulate the catalytic behavior of native enzymes. According to the wide studies in this area, the substrate recognition, specifically supramolecular interactions, and the cooperativity between the catalytic sites and substrate-binding sites have been regarded as pivotal factors for designing an efficient artificial enzyme. Up to now, large numbers of artificial enzymes have been constructed on various different scaffolds ranging from small molecular compounds, polymers, biomacromolecules to supramolecular assemblies and nanomaterials. Although most of the artificial enzymes showed moderate catalytic activities, encouragingly, some of them exhibited exciting high efficiency and selectivity. Compared to other scaffolds, macromolecules with their own advantages can endow enzyme models with enriched catalytic sites as well as the easy-achieved cooperation of the catalysis and recognition. This review will give an overview of the construction of artificial enzymes using macromolecules as scaffolds in the past decades, wherein various macromolecules containing copolymers, dendrimers, hyperbranched polymers, polymer microgels, supramolecules, imprinted polymers and biomacromolecules have been developed as scaffolds of artificial enzymes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Polymer Science - Volume 37, Issue 11, November 2012, Pages 1476-1509
Journal: Progress in Polymer Science - Volume 37, Issue 11, November 2012, Pages 1476-1509
نویسندگان
Yanzhen Yin, Zeyuan Dong, Quan Luo, Junqiu Liu,