کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5209007 1503019 2007 39 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymer systems for gene delivery-Past, present, and future
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Polymer systems for gene delivery-Past, present, and future
چکیده انگلیسی
Gene therapy has long sought to treat disease by delivering therapeutic genes to diseased cells. However, its widespread clinical use has faltered in the face of several challenges, most notably in the area of delivery. Efforts to understand the biological barriers that prevent the effective delivery of therapeutic genes to targeted tissues, and developing safe and efficient vectors that can overcome the barriers, stand at the heart of current gene delivery research. The first part of this review provides a comprehensive discussion of the current understanding of these biological barriers and the rich collection of polymers and design strategies that have accumulated from nearly two decades of research aimed at overcoming these hurdles. The second part highlights the challenges that remain and several innovative approaches and methods that have recently been developed representing, in part, the future directions of gene delivery research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Polymer Science - Volume 32, Issues 8–9, August–September 2007, Pages 799-837
نویسندگان
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