کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5210107 | 1382874 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thiomer: A potential carrier for therapeutic delivery
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The major challenge for any drug delivery system is the attainment of effective bioavailability without affecting the protective physiological mechanisms within the body. Systems based on mucoadhesive polymers have been widely preferred as these polymers not only prolong the residence time of the system on mucosal surfaces, but also retarded drug elimination. Mucin is one of the prominent targets to improve drug retention by enhancing adhesion between polymer and mucus membrane. Thiomers are modified mucoadhesive polymers that possess thiol bearing side chains display enhanced mucoadhesion that could be attributed to the formation of disulfide bonds between thiolated polymers and cysteine-rich subdomains of mucus glycoproteins. This review proposes the potential of thiomer as a promising and effective carrier for delivery of therapeutics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 73, Issue 8, August 2013, Pages 1156-1166
Journal: Reactive and Functional Polymers - Volume 73, Issue 8, August 2013, Pages 1156-1166
نویسندگان
Rakesh Kumar, V.R. Sinha,