کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5210135 | 1382876 | 2012 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of glycopoly(pseudo amino acid)s and their interaction with lectins Synthesis of glycopoly(pseudo amino acid)s and their interaction with lectins](/preview/png/5210135.png)
In this study, we developed a novel bioeliminable amphiphilic glycopoly(pseudo amino acid), which was synthesized by the condensation polymerization of N-benzyloxycarbonyl-4-hydroxyl-l-proline (NZHpr) followed by the coupling of an alkynyl-functional sugar derivative to the azido-end group, P(NZHpr)n. The glycosylated P(NZHpr)n polymers formed micelles in the aqueous phase. Selective lectin binding experiments confirmed that the glycosylated P(NZHpr)n can be used in biorecognition applications. The DOX-loaded micelles facilitated improved uptake of DOX by HeLa cells within 2Â h and were primarily retained in the cytoplasm, whereas free DOX tended to accumulate in the nuclei. The DOX-loaded glucosylated P(NZHpr)n micelles exhibited a substantially lower cytotoxicity compared to free DOX.
Journal: Reactive and Functional Polymers - Volume 72, Issue 9, September 2012, Pages 564-573