کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5210204 | 1382880 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mixed micelles from methoxy poly(ethylene glycol)-polylactide and methoxy poly(ethylene glycol)-poly(sebacic anhydride) copolymers as drug carriers
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mixed micelles from methoxy poly(ethylene glycol)-polylactide and methoxy poly(ethylene glycol)-poly(sebacic anhydride) copolymers as drug carriers Mixed micelles from methoxy poly(ethylene glycol)-polylactide and methoxy poly(ethylene glycol)-poly(sebacic anhydride) copolymers as drug carriers](/preview/png/5210204.png)
چکیده انگلیسی
mPEG-PLLA (poly l-lactic acid) is synthesized by ring-opening polymerization of lactide and conjugation with mPEG. Sebacic acid is modified with acetic anhydride and condensed with mPEG to form mPEG-PSA (poly sebacic anhydride). The micelles formed by mPEG-PLLA are characterized by slow degradation and low drug encapsulation efficiency; on the contrary, mPEG-PSA micelles are characterized by rapid degradation but high encapsulation efficiency. They can merge into spherical micelles (Φ = 140 nm) by self-assembly in water. The mixed micelles can successfully encapsulate a typical hydrophobic drug (curcumin), and significantly improve its solubility. Experimental results show that the mixed micelles have the features of high encapsulation efficiency and slow degradation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 72, Issue 11, November 2012, Pages 846-855
Journal: Reactive and Functional Polymers - Volume 72, Issue 11, November 2012, Pages 846-855
نویسندگان
Po-Liang Lai, Cheng-Chun Hsu, Tsang-Hao Liu, Ding-Wei Hong, Lih-Huei Chen, Wen-Jer Chen, I-Ming Chu,