کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5210622 | 1382906 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional and reactive polymethacrylates suitable for preparation of peptide/protein-polymer conjugates
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Functional and reactive polymethacrylates suitable for preparation of peptide/protein-polymer conjugates Functional and reactive polymethacrylates suitable for preparation of peptide/protein-polymer conjugates](/preview/png/5210622.png)
چکیده انگلیسی
Three reactive polymers, poly(para-nitrophenoxycarbonyloxyethyl methacrylate-co-methyl methacrylate) P(p-NPCEMA-co-MMA) [rCoP1], poly(methyl methacrylate-co-butyl methacrylate-co-allyl methacrylate-co-phenoxycarbonyloxyethyl methacrylate) P(MMA-co-BMA-co-AMA-co-PCEMA) [rCoP2] and poly(methyl methacrylate-co-dimethylaminopropyl methacrylate-co-dodecyl methacrylate-co-phenoxycarbonyloxyethyl methacrylate) P(MMA-co-DMAPMA-co-DMA-co-PCEMA) [rCoP3], respectively, were prepared following two synthetic concepts. Following the first concept, p-NPCEMA and PCEMA were prepared starting with commercially available HEMA and were copolymerized via ATRP with MMA, BMA and AMA. According to the second concept phenoxycarbonyloxy decorated polymethacrylates were obtained via polymer analogous reaction of a HEMA containing functional polymethacrylate, P(MMA-co-DMAPMA-co-DMA-co-HEMA) [fCoP], obtained via a cascade reaction of enzymatic transacylation and free radical polymerization. The highly reactive poly(methacrylate)s and silk peptides, hen egg-white lysozyme and Candida antarctica lipase B were used for the preparation of protein/peptide-poly(methacrylate) bioconjugates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 70, Issue 10, October 2010, Pages 767-774
Journal: Reactive and Functional Polymers - Volume 70, Issue 10, October 2010, Pages 767-774
نویسندگان
Dragos Popescu, Helmut Keul, Martin Möller,