Structural verification via convergent total synthesis of dipeptide-lipids isolated from Porphyromonas gingivalis

91We have proven the structure of lipid 654, isolated from the dental pathogen Porphyromonas gingivalis. The lipid was prepared by a convergent synthetic route that is significantly shorter than other published routes, producing the targeted compound in higher yield. Further, we have shown that this dipeptide-lipid is selectivity hydrolyzed by lipase, consistent with results from lipid 654 obtained from P. gingivalis.