کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5214068 | 1383183 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Eight new alkaloids with PTP1B and α-glucosidase inhibitory activities from the medicinal mushroom Hericium erinaceus
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Eight new alkaloids (1-8), were isolated from the solid culture of Hericium erinaceus. The structures of new metabolites were established by spectroscopic methods. The absolute configuration of 1 was determined by electronic circular dichroism (ECD) calculation. Compounds 5-8 showed inhibitory activities against both protein tyrosine phosphatase-1B (PTP1B) and α-glucosidase. In the cytotoxicity assay, compounds 1-4 showed moderate cytotoxicity against K562 cells with IC50 values in the range of 11.4-18.2 μM, and also weak cytotoxicity against doxorubicin resistant K562 cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 71, Issue 51, 23 December 2015, Pages 9557-9563
Journal: Tetrahedron - Volume 71, Issue 51, 23 December 2015, Pages 9557-9563
نویسندگان
Kai Wang, Li Bao, Ke Ma, Ning Liu, Ying Huang, Jinwei Ren, Wenzhao Wang, Hongwei Liu,