کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5217830 1383308 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of the acylphloroglucinols rhodomyrtone and rhodomyrtosone B
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of the acylphloroglucinols rhodomyrtone and rhodomyrtosone B
چکیده انگلیسی

In a sequential three-component coupling syncarpic acid, 3-methylbutanal and an acylated phloroglucinol were combined to the hydroxy ketone 3. Acid catalysis converted 3 directly to the natural product rhodomyrtosone B (2). The other isomer, the antibiotic rhodomyrtone (1) was obtained from 3 in a sequence of acid-catalyzed cyclization, retro Friedel-Crafts reaction, and reacylation. In preliminary assays both compounds showed potent antibiotic activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 69, Issue 40, 7 October 2013, Pages 8559-8563
نویسندگان
, , , ,