Catalytic asymmetric synthesis of cyclic α-alkyl-amino acid derivatives by C,N-double alkylation

Catalytic asymmetric synthesis of various cyclic α-alkyl-amino acid derivatives having a tetrasubstituted α-carbon, such as α-alkylprolines has been accomplished by asymmetric phase-transfer C-alkylation of α-alkyl-amino acid derivatives and subsequent intramolecular N-alkylation.