Enantioselective CD analysis of amino acids based on chiral amplification with a stereodynamic probe

Stereodynamic 1,8-bis(3′-formyl-4′-hydroxyphenyl)naphthalene, 1, reacts with two amino acid molecules to a rigid chiral diimine scaffold showing distinctive Cotton effects. In situ CD analysis of the reaction mixture provides information on the enantiomeric excess and the absolute configuration of the substrate.