کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5224191 | 1383509 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytotoxic principles and α-pyrone ring-opening derivatives of bufadienolides from Kalanchoe hybrida
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cytotoxic principles and α-pyrone ring-opening derivatives of bufadienolides from Kalanchoe hybrida Cytotoxic principles and α-pyrone ring-opening derivatives of bufadienolides from Kalanchoe hybrida](/preview/png/5224191.png)
چکیده انگلیسی
Purification of the cytotoxic fractions of the methanol extracts of Kalanchoe hybrida leads to three new compounds with the basic skeleton of α-pyrone ring-opening products of bufadienolides, namely, kalanhybrin A-C (1-3). Moreover, four bufadienolides (4-7) and eight other compounds were also characterized from the title plant. The isolated compounds (1-7) were evaluated for their cytotoxicity toward MCF-7, NCI-H460, and SF-268 tumor cell lines. Among them, compounds 4 and 6 displayed significant cytotoxicity toward MCF-7 and NCI-H460 tumor cell lines at the tested concentration. In addition, the biosynthetic pathway of these α-pyrone ring-opening derivatives was also proposed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 64, Issue 15, 7 April 2008, Pages 3392-3396
Journal: Tetrahedron - Volume 64, Issue 15, 7 April 2008, Pages 3392-3396
نویسندگان
Ping-Chung Kuo, Tsung-Hsiao Kuo, Chung-Ren Su, Meei-Jen Liou, Tian-Shung Wu,