کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5225161 1383539 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enantioselective cyanosilylation of aldehydes catalyzed by a novel N,N′-dioxide-Ti(OiPr)4 bifunctional catalyst
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Enantioselective cyanosilylation of aldehydes catalyzed by a novel N,N′-dioxide-Ti(OiPr)4 bifunctional catalyst
چکیده انگلیسی

A novel bifunctional asymmetric catalyst containing N-oxide and titanium(IV) was developed and applied to the asymmetric cyanosilylation of aldehydes. Optically active trimethylsilyl cyanohydrin ethers were obtained up to 99% yield and 80% ee in the presence of 5 mol % catalyst loading at −78 °C. Based on the experimental results, the catalytic cycle was proposed as a pathway in which Lewis acid and Lewis base activated aldehyde and trimethylsilylcyanide (TMSCN), respectively.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron - Volume 63, Issue 24, 11 June 2007, Pages 5129-5136
نویسندگان
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