کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5264964 | 1385271 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A coumarinylaldoxime as a specific sensor for Cu2+ and its biological application
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A coumarinylaldoxime as a specific sensor for Cu2+ and its biological application A coumarinylaldoxime as a specific sensor for Cu2+ and its biological application](/preview/png/5264964.png)
چکیده انگلیسی
In this Letter we present a new probe, (E)-7-(diethylamino)-2-oxo-2H-chromene-3-carbaldehyde oxime (JB), which can detect Cu2+ ions in HEPES buffer under physiological conditions. Benesi-Hildebrand and Job plots demonstrate that the stoichiometry of the Cu2+ complex formed is 2:1. Possible interference with other analytes was examined, and the decrease of the fluorescence of JB at 510Â nm when it reacts with Cu2+ was shown to be highly selective. This probe accumulates in the plasmalemma of human neuroblastoma SH-SY5Y cells. Molecular dynamics (MD) simulations revealed that JB interacts with the lipid bilayer at the level of the glycerol moieties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 55, Issue 4, 22 January 2014, Pages 873-876
Journal: Tetrahedron Letters - Volume 55, Issue 4, 22 January 2014, Pages 873-876
نویسندگان
Olimpo GarcÃa-Beltrán, Bruce K. Cassels, Natalia Mena, Marco T. Nuñez, Osvaldo Yañez, Julio Caballero,