کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5265836 1385295 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Double nucleophilic N-alkylation of α-oxime-esters with Grignard reagents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Double nucleophilic N-alkylation of α-oxime-esters with Grignard reagents
چکیده انگلیسی
Double nucleophilic N-alkylation of α-oxime-esters, affording N,N-dialkyl-α-amino acids is herein described. Grignard reagents accomplished double N-alkylations via umpolung and various N,N-dialkylated α-amino acids were successfully synthesized in 15 min. Both electron-withdrawing sulfonyl groups and electron-donating silyl and methyl groups on oximes were available. Alkylmagnesium species and (E)-configuration of α-oxime-ester were essential to this cascade reaction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 53, Issue 44, 31 October 2012, Pages 5903-5906
نویسندگان
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