Palladium-catalyzed synthesis of benzo[c]pyrimido[1,6-a]azepine scaffold from Morita-Baylis-Hillman adducts: intramolecular 6-arylation of uracil nucleus

Palladium-catalyzed intramolecular arylation at the C-6 position of uracil moiety was examined. Morita-Baylis-Hillman adducts bearing an uracil moiety at the primary position served an efficient way to a benzo[c]pyrimido[1,6-a]azepine scaffold.