کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5274030 | 1385503 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography](/preview/png/5274030.png)
چکیده انگلیسی
A resin linked with the Tamiflu core was synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resin bound to the influenza virus enzyme neuraminidase, the main target of Tamiflu. The immobilized Tamiflu analog will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the abnormal behavior exhibited by some influenza patients treated with Tamiflu.
An immobilized Tamiflu analog for affinity chromatography was synthesized to identify possible endogenous target proteins in vertebrates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 50, Issue 26, 1 July 2009, Pages 3205-3208
Journal: Tetrahedron Letters - Volume 50, Issue 26, 1 July 2009, Pages 3205-3208
نویسندگان
Yasuaki Kimura, Kenzo Yamatsugu, Motomu Kanai, Noriko Echigo, Takashi Kuzuhara, Masakatsu Shibasaki,