کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5279851 1385634 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amino acid catalyzed direct enantioselective formation of carbohydrates: one-step de novo synthesis of ketoses
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Amino acid catalyzed direct enantioselective formation of carbohydrates: one-step de novo synthesis of ketoses
چکیده انگلیسی

The amino acid-catalyzed direct enantioselective one-step de novo synthesis of carbohydrates using dihydroxyacetone phosphate mimetics as donors and aldehydes or in situ generated imines as acceptors is presented. The addition of water significantly accelerates as well as improves the enantioselectivity of the biomimetic aldol and Mannich reactions. The C3+Cn methodology presented herein is a direct entry to orthogonally protected C-5 and C-6 ketoses (e.g., ribulose, tagatose and piscose) and deoxy- and aminosugars such as 4-amino-4-deoxy-fructose.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 46, Issue 19, 9 May 2005, Pages 3363-3367
نویسندگان
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