Insight into estrogen receptor beta-beta and alpha-beta homo- and heterodimerization: A combined molecular dynamics and sequence analysis study

► ER forms highly stable heterodimer which is more stable than the ERββ homodimers. ► ERα and ERβ share very similar electrostatic potential profile of dimer interface. ► In essential subspace, the homo- and heterodimer dynamics are distinctively different. ► The dimer interface of the LBD in both the ERs is highly conserved. ► Phylogenetic analysis reveals a co-evolutionary signature between the two receptors.