Application of Box-Behnken design in the optimization of new peroxyoxalate-H2O2 chemiluminescence system using furan derivatives as blue activators

► Furan derivatives are used as activators for peroxyoxalate chemiluminescence. ► The activators produce a blue light in the chemiluminescence system. ► The Box-Behnken design matrix and response surface methodology (RSM) is used. ► The most important variables are sodium salicylate, furan and hydrogen peroxide. ► The data are fitted to a second-order polynomial equation for CL emission of TCPO.