A sensitive inhibition chemiluminescence method for the determination of 6-mercaptopurine in tablet and biological fluid using the reaction of luminol-Ag(III) complex in alkaline medium

► A sensitive inhibition chemiluminescence (CL) method for the determination of 6-MP is developed. ► The inhibition mechanism of 6-MP on the CL emission was proposed. ► The detection limit was 3.7×10−10 g ml−1. ► The accuracy was examined by comparing with the pharmacopoeia method.