Interactions between β-carboline alkaloids and bovine serum albumin: Investigation by spectroscopic approach

► We model the binding of β-carboline alkaloids to BSA by using the spectroscopic methods. ► We investigate the effects of drug complexation on BSA stability and conformation. ► A partial protein destabilization occurred at high alkaloids concentration. ► Alkaloids bind BSA via hydrophobic interactions and H-bonding with the NH groups. ► BSA can be considered as a good carrier for transportation of β-carboline alkaloids.